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OpenArray® Pathways are ready-to-use gene panels containing bench-validated real-time qPCR assays. An alternative to custom-designed assays, the Pathways panels offer researchers a comprehensive and complete set of gene families to aid the study of cancer, cardiovascular disease, inflammatory disease and basic cellular systems.
Each plate in the Pathways product family contains 600+ laboratory tested assays. You will be able to significantly increase the number of samples analyzed while decreasing the time and cost required.
Human and Mouse qPCR Assay Panels
Click on any of the links below to view a full list of genes configured on the plate. To find out how the OpenArray Pathways products can benefit your research, please contact us.
Human gene panels:
Mouse gene panels:
One OpenArray plate has 3072 through-holes, the same as eight 384-well plates.
Human Panels
ADME
Toxicology, drug metabolism and drug transport are processes covered by this panel. Genes for Phase I and Phase II metabolizing enzymes are well represented, as are the genes encoding ABC and SLC transporters.
Click here for list of Human ADME gene assays.
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Apoptosis
Genes involved in apoptosis have been linked to major disease processes, such as CVD, oncogenesis and inflammation. This panel has genes from the BCL, caspase and TNF families as well as p53 and other genes encoding DNA damage proteins.
Click here for list of Human Apoptosis gene assays.
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Cancer
The cancer panel covers DNA repair, angiogenesis, cell adhesion and ECM. In addition, it includes apoptosis, cell cycle and many of the genes encoding kinases and transcription factors that have been found to be differentially expressed in early cancer and metastatic disease.
Click here for list of Human Cancer gene assays.
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Cardiovascular Disease
The disparate pathways that lead to cardiovascular disease are represented in this diverse panel of genes, from ECM, hypoxia, NO and oxidative stress pathways to genes involved in lipid metabolism, platelet activation and apoptosis. This CVD panel is comprehensive with assays for genes involved in blood pressure regulation and atherosclerosis along with genes encoding key ion channel components.
Click here for list of Human Cardiovascular gene assays.
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Drug Targets
This panel contains assays for genes that are common drug targets. Using these assays to identify and follow surrogate markers, pharmaceutical researchers can test drug MOA, off-target effects and compound efficacy. The Drug Targets panel erases some of the rate-limiting steps in conventional high-throughput drug screening.
Click here for list of Human Gene Drug Targets assays.
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GPCRs
The G-protein coupled receptors (GPCRs) panel includes bench-validated assays for genes involved in such diverse processes as sensory input, behavior, immune system regulation and autonomic nervous system transmission. Signal transduction, drug development, immune system and brain researchers will find this panel indispensable in their research.
Click here for list of Human G-Protein Receptor gene assays.
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Human Housekeeping
The human housekeeping panel was developed as a control for gene expression analysis studies to compare the expression of unknown genes to the expression of standard housekeeping genes. This set of 18 housekeeping genes are expressed constitutively in most cells because they encode proteins that are necessary for the cell\u2019s functionality, including RNA and DNA binding proteins.
Click here for list of Human Housekeeping gene assays.
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Inflammation
This panel encompasses genes involved in the key pathways of inflammation response, including major chronic autoimmune diseases and acute immune response. Some of the key gene families on this panel are cytokines, including interleukins, chemokines and their receptors also BMP and TNF families, Toll and STAT pathway members and genes encoding B- and T-cell activation proteins.
Click here for list of Human Inflammation Response gene assays.
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Kinome
The human kinome panel was developed to analyze the expression of kinase genes as well as genes that express proteins that are part of kinase complexes, bind kinases or whose annotation as kinases have not yet been fully validated. This panel includes 801 kinase and kinase-related genes.
Click here for list of Human Kinome gene assays.
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Signal Transduction
This wide-ranging panel covers the major signaling pathways including JAK-STAT, NFkB, Akt, GPCR, cAMP and MAP kinase. The complete pathway is covered from ligand to receptor to kinase to transcription factor.
Click here for list of Human Signaling Pathways gene assays.
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Transcription Factors
Regulatory pathways are highly complex, with multiple transcription factors affecting the expression of multiple genes. The Transcription Factors panel contains bench-validated assays for genes in the Wnt pathway, immune cell signaling pathways, MAPK pathway, NFkB and PDGF pathways, to name a few. This panel allows researchers to very easily answer hypotheses concerning gene regulation and pathway associations.
Click here for list of Human Transcription Factors assays.
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Mouse Panels
Cardiovascular Disease
Ideal for the study of cardiovascular disease genes, this panel contains primers for genes involved in murine cardiovascular development and disease processes, including lipid metabolism, platelet activation, blood pressure regulation and atherosclerosis.
Click here for list of Mouse Cardiovascular Disease gene assays.
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Inflammation
Designed to study key pathways and components of the murine inflammation response, this panel contains assays for genes encoding cytokines, chemokines, interleukins, and genes encoding B- and T-cell activation proteins.
Click here for list of Mouse Inflammation Response gene assays.
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Transcription Factors
Defining the regulatory steps in murine models of human diseases, this panel is perfect for use in two-state comparisons as well as time-courses involving knockouts, siRNA or miRNA transfections and drug treatments.
Click here for list of Mouse Transcription Factors assays.
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